Disulfiram generic


Disulfiram Generic

Abstain for at least 12 hrs. Initially mg once daily for 1—2 weeks then mg once daily; max mg daily. Continue until patient develops basis for self-control. Severe cardiovascular disease. Allergy to thiuram in pesticides and rubber.

The patient should not take disulfiram for at least 12 hours after drinking. A reaction may occur for up to 2 weeks after disulfiram has been stopped. Disulfiram is used to treat chronic alcoholism. It causes unpleasant effects when even small amounts of alcohol are consumed. These effects include flushing of the face, headache, nausea, vomiting, chest pain, weakness, blurred vision, mental confusion, sweating, choking, breathing difficulty, and anxiety. Disulfiram is not a cure for alcoholism, but discourages drinking. Disulfiram comes in tablets to take by mouth.


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What is Antabuse, and how does it work mechanism of action? Disulfiram is an oral drug used for treating alcoholism. Disulfiram prevents acetaldehyde dehydrogenase from converting acetaldehyde into acetic acid, leading to a buildup of acetaldehyde levels in the blood. Is Antabuse available as a generic drug? What are the uses for Anabuse? Antabuse is used of treating alcoholism. Antabuse should never be given to a patient who is intoxicated, or without his or her full knowledge. Relatives of patients should be advised about this warning also.

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Disulfiram is an alcohol deterrent used as an adjunct to treatment of chronic alcoholism, based upon its ability to cause an aversive reaction when taken with alcohol. Disulfiram has been associated a low rate of with serum aminotransferase elevations during chronic therapy and has been linked to clinical apparent acute liver injury which can be severe and result in fatality. Disulfiram dye sul' fi ram is tetraethylthiuram disulfide and is a potent inhibitor of aldehyde dehydrogenase activity, which interferes with the oxidative metabolism of alcohol resulting in accumulation of acetaldehyde. The elevations in serum acetaldehyde levels cause the aversive symptoms of disulfiram which include flushing, headache, nausea, vomiting and sweating and can result in dizziness, blurred vision, dyspnea, palpitations, hypotension, chest pain and syncope. Disulfiram was developed as an antihelminthic, but was then pursued as a possible alcohol deterrent when its aversive effects upon alcohol intake were found. Disulfiram was approved for use in the United States in and has been widely used in management of alcoholism, but in recent years has fallen out of favor because of its difficult side effects.


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A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance disulfiram generic administered alone, but markedly alters the intermediary metabolism of alcohol. It acts by inhibiting aldehyde dehydrogenase. Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase, which acts in the second step of ethanol utilization. In addition, disulfiram competitively binds and inhibits the peripheral benzodiazepine receptor, which may indicate some value in the treatment of the symptoms of alcohol withdrawal, however this activity has not been extensively studied. Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Disulfiram Generic


Maintenance: mg PO qDay mg range ; continue therapy until a bases for self-control has been established; patient may continue to take drug therapy for months or even years. Never administer to a patient in a state of alcohol intoxication or without patient's full knowledge. Produces sensitivity to EtOH via blocking its oxidation at acetaldehyde stage, resulting in unpleasant reactions including palpitations, hypotension, chest pain, nausea, vertigo, thirst, flushing, and nausea. Your list will be saved and can be edited at any time. Significant - Monitor Closely.


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There are seven drug master file entries for disulfiram. Five suppliers are listed for this compound. Serving leading biopharmaceutical companies globally Drugs may be covered by multiple patents or regulatory protections. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data.


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Disulfiram plus alcohol, even small amounts, produces flushing, throbbing in the head and neck, a throbbing headache, respiratory difficulty, nausea, copious vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, fast heart rate, low blood pressure, fainting, marked uneasiness, weakness, vertigo, blurred vision, and confusion. In severe reactions there may be respiratory depression, cardiovascular collapse, abnormal heart rhythms, heart attack, acute congestive heart failure, unconsciousness, convulsions, and death. In the body, alcohol is converted to acetaldehyde, which is then broken down by acetaldehyde dehydrogenase. When the dehydrogenase enzyme is inhibited, acetaldehyde builds up, causing unpleasant side effects. Disulfiram has been studied as a possible treatment for cancer 2 and latent HIV infection. Disulfiram is used as a second line treatment, behind acamprosate and naltrexone, for alcohol dependence.

disulfiram generic


Disulfiram should never be administered to a patient when he is in a state of alcohol intoxication, or without his full knowledge. Disulfiram is an alcohol antagonist drug. Disulfiram occurs as a white to off-white, odorless, and almost tasteless powder, soluble in water to the extent of about 20 mg in mL, and in alcohol to the extent of about 3. Each tablet for oral administration contains mg or mg disulfiram, USP. Tablets also contain colloidal silicon dioxide, anhydrous lactose, magnesium stearate, microcrystalline cellulose, sodium starch glycolate, and stearic acid.

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Disulfiram generic

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