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Due to strict testing of new drugs during the developmental stages this should be a rare phenomenon. However, some drugs through immunosuppression, are known to increase the risk of tumour formation. For example, drugs used to treat cancers and drugs used to prevent transplant rejection are known to do this. It is important to realize that these are principles that have been derived from standard studies of drug action on вaverageв or вnormalв individuals during the development process for new drugs.
In some cases where there is involvement of only a few joints, corticosteroids (usually triamcinolone or hydrocortisone) can be administered locally by intra-articular injection to relieve pain, increase mobility and reduce deformity. Methylprednisolone has recently been added to the list of drugs that registered podiatrists can administer by injection into soft tissue injury. Registered physiotherapists can administer corticosteroids by injection according to patient group directions.
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This process is known as translation. Each amino acid is coded for by a sequence of three bases, known as a triplet code. For example, ACA codes for the amino acid cysteine. As amino acids are added in sequence a protein is built up.
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The stated outcomes of PGDs are: в Understand the concept of patient group directions в Understand the historical and legal background to patient group directions в Understand the meanings of pharmacodynamics and pharmacokinetics in relation to the drugs that the radiographer is able to supply and administer в Understand the pathophysiological processes in the conditions under which the patient group directions can be used в Understand the protocols and guidelines that exist to support the use of patient group directions.
Supplementary prescribing courses are offered by universities and these are open to all professions that are legally permitted to hold these responsibilities. Presently, ring-fenced monies from the Department of Health are managed by Strategic Health Authorities to fund these courses in an attempt to promote non-medical prescribing.
There will come a point, however, when this funding is withdrawn. All Trust and university-based training offered to radiographers in this area is normally on a multi-professional basis.
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The original О-blockers did not discriminate between О drugs have been developed that are more cardio-selective and there are others that also cause vasodilation. First generation О-blockers are non-cardio-selective and they can produce bronchoconstriction as an adverse effect. They exacerbate congestive heart failure, adversely affect plasma lipid profiles and reduce exercise tolerance.
An example is propranolol. Second generation О-blockers have greater cardio-selectivity and are less likely to cause bronchoconstriction.