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Adverse reactions to anti-inflammatory corticosteroids are summarized This is a diverse group of drugs that do not inhibit COX; neither do they have analgesic or direct anti-inflammatory activity. They appear to suppress the disease process in rheumatoid arthritis and other chronic inflammatory conditions and may cause remission of disease. These are the disease-modifying antirheumatic drugs.
Unlike NSAIDs and corticosteroids, they do not produce an immediate therapeutic effect but require four to six months of treatment for a full response.
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Acute side effects of PUVA treatment are nausea from the psoralen and blistering and erythema from the UVA. UVA is principally responsible for photo-ageing and penetrates tissues far more deeply than UVB. Long-term risks of PUVA include accelerated skin ageing and an increased incidence of skin cancer. Patients must not be taking other photosensitizing drugs, for example phenothiazines and benzodiazepines, NSAIDs and some antibiotics.
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This may be useful in the event of an overdose. Conversely, the elimination of basic drugs such as amfetamine, antihistamines, morphine and tricyclic antidepressants can be increased by making tubular filtrate more acidic by administration of ammonium chloride. Although generally not as important as renal excretion, other routes of excretion account for elimination of some drugs. It is possible for drugs to move back across the intestinal wall by diffusion or active transport and be lost in faeces.
Some drugs, particularly hormones, can also be excreted into the intestine via bile.
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All are either sodium salts or meglumine salts or mixture of the two. Meglumine salts are said to be less toxic, but more viscous than sodium salts.
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PAcetylcholine binds to the О lumps.
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A podiatrist has studied for three years to obtain a degree in podiatric medicine and Registration.
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