Tamoxifen is a hormone therapy for breast cancer in both women and men. It lowers the risk of early breast cancer coming back recurring after surgery or developing in the other breast. It can also control advanced breast cancer for some time. Tamoxifen is sometimes used in women who have a high risk of breast cancer, to prevent breast cancer from developing. Many breast cancers are stimulated to grow by the female sex hormones oestrogen and progesterone.
Prices are for cash paying customers only and are not valid with insurance plans. Important: When there is a range of pricing, consumers should normally expect to pay the lower price. There are currently no Manufacturer Promotions that we know about for this drug. Eligibility requirements vary for each program. There are currently no Patient Assistance Programs that we know about for this drug. Other brands: Nolvadex, Soltamox.
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It is only for research purposes and not for human consumption. It competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. This results in a reduction in DNA synthesis and cellular response to estrogen. Liquid tamoxifen exhibits both estrogenic agonist and antagonist effects in different parts of the body of animal test subjects. In the breast tissue, it is an antagonist, causing antiestrogenic and antitumor effects. Through downstream intracellular processes, it slows cell cycling, which classifies it as cytostatic. In the bone, it stimulates estrogen receptors instead of blocking them, exerting an estrogenic agonist effect, and may prevent osteoporosis. In experimental animals, concentrations of tamoxifen and its metabolites are 8- to fold higher in tissues brain, adipose, liver, heart, lung, kidney, uterus, testis than in serum.
The product received US Food and Drug Administration marketing approval in October and is indicated for the treatment of metastatic breast cancer and to reduce the incidence of breast cancer in women who are at high risk for the disease. Becker, president and tamoxifen liquid price executive officer of Cytogen. Dysphagia is a common complication of cancer therapy, resulting in particular from treatment involving radiation or chemotherapy. Cancer patients with dysphagia experience problems swallowing pills due to mouth and throat sores, inflammation, or dry mouth. This can lead to risks including altered dosing efficacy or side effects associated with improper dosing.
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Both of these drugs are selective estrogen receptor modulators SERMs. This means that they act against or block estrogen a female hormone in some tissues of the body, but act like estrogen in others. Estrogen can fuel the growth of breast cancer cells. Both of these drugs block estrogen in breast cells, tamoxifen liquid price is why they can be useful in lowering breast cancer risk. To lower the risk of breast cancer, these drugs are taken for 5 years. Both drugs are pills taken once a day.
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Tamoxifen is a drug that has been in worldwide use for the treatment of estrogen receptor ER -positive breast cancer for over 30 years; it has been used in both the metastatic and adjuvant settings. Despite these positive findings, however, the public's attitude toward breast cancer chemoprevention remains ambivalent, and the toxicities associated with tamoxifen, particularly endometrial cancer and thromboembolic events, have hampered the drug's uptake by high-risk women who should benefit from its preventive effects. Among the strategies to overcome such obstacles to preventive tamoxifen, two novel and potentially safer modes of delivery of this agent are discussed in this paper. Low-dose tamoxifen, expected to confer fewer adverse events, is being investigated in both clinical biomarker-based trials and observational studies. Avoidance of systemic administration is expected to reduce the distribution of drug to tissues susceptible to tamoxifen-induced toxicity. At present, tamoxifen is the only proven oral agent for the adjuvant hormonal treatment of hormone receptor-positive breast cancer in premenopausal women 1, and it can be used in both pre- and postmenopausal women who are at increased risk of breast cancer 2.
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