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The dose of levodopa can be reduced and there is evidence that this combination has a neuroprotective effect and slows the progression of the disease. This may be because in Parkinsonвs disease, MAO-B is involved in the production of an endogenous neurotoxin.
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Unexpected reactions to drugs can occur in children.
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Supplementary prescribing can be suitable in some areas of community physiotherapy.
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In addition, changes in the synthesis of collagen occur resulting in thinning and loss of the mechanical resistance in the skin.
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Radioactive iodine is also used to treat thyrotoxicosis.
Xanthines are of principle use in the immediate phase reaction of asthma but also have some effect on the late phase reaction. They are used to treat severe acute asthma attacks and chronic asthma, in particular control of nocturnal asthma and early morning wheezing.
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Addition of water. Enzymes capable of catalysing hydrolysis are found in many body tissues but particularly in the small intestine.
The serum is rheumatoid factor negative. Most rheumatic diseases require symptomatic treatment to relieve pain and increase joint movement using non-steroidal anti-inflammatory drugs and anti-inflammatory corticosteroids to limit or stop the inflammation. In addition treatment aims to prevent destruction of joints by the use of disease-modifying antirheumatic drugs. Indeed, use of DMARDs early on in the disease process is now recommended. The British Society for Rheumatology produces clinical guidelines for treatment of rheumatic diseases.
Transport systems exist for the secretion of acidic substances, for example uric acid and basic substances, for example creatinine. Many drugs can be actively secreted by this mechanism, which increases their rate of removal from the body. Active transport does not depend on concentration gradients and can overcome plasma protein binding. As the free drug is transported, more of the drug dissociates from the protein binding site and can be eliminated.
Substances transported by the same transport system compete with each other and the more slowly a drug is transported the more effective it is at inhibiting the transport of another.