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Potentially Fatal: Respiratory depression. Possible increase in anticoagulation with warfarin. Reduced analgesic efficacy of tramadol with carbamazepine, 5-HT3-receptor antagonist e. Suicidal patients, acute alcoholism; head injuries; raised intracranial pressure; severe renal impairment; lactation. Tramadol inhibits reuptake of norepinephrine, serotonin and enhances serotonin release. It alters perception and response to pain by binding to mu-opiate receptors in the CNS.
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Drugs used to treat cancer act on some stage in the cell cycle, either on DNA synthesis or spindle formation; or cause damage to preformed DNA. Phase-specific drugs act at a particular point in the cycle, usually S phase or M phase.
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Examples are atenolol and bisoprolol.
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Conversely, the elimination of basic drugs such as amfetamine, antihistamines, morphine and tricyclic antidepressants can be increased by making tubular filtrate more acidic by administration of ammonium chloride.
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Resistance can occur through a number of consequences of viral mutation.
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As an alternative to listing medicines individually, the CMP may refer to recognized and accepted local or national clinical guidance in written or electronic form.
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It is not known why these effects occur, but they may be due to advance of the disease process.
Drugs have been developed to inhibit reverse transcriptase and are used particularly to treat HIV. Some drugs in this group are also nucleoside analogues; others are not.
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Radiography, Hogg, P. Hogg, D.
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Renin together with angiotensin-converting enzyme produces angiotensin II, which is a powerful vasoconstrictor and stimulates the release of aldosterone from the adrenal glands. Figure shows the renin-angiotensin-aldosterone pathway. Vasoconstriction and the salt and water reabsorption activity of aldosterone result in restoration of blood volume and therefore blood pressure.
In cardiac failure, cardiac output is reduced. This means initially that with exercise the organs and tissues do not have an adequate blood supply. As the condition progresses the supply may not be sufficient even at rest.
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