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Hypersensitivity reactions to drugs involve immunological reactions. Large molecules such as vaccines, insulin and dextrans can provoke immune reactions themselves but most drugs are too small to be antigenic on their own. In some patients, something that cannot be predicted is that a drug or drug metabolite can combine with tissue proteins to form an antigenic conjugate.
In both cases, the administrator was personally responsible for posting out these medicines to the patient, in accordance with a PGD. There is a second problem associated with this arrangement, regarding the use of the postal service as part of a PGD arrangement. Where does liability rest. With the administrator or with the postman (who unknowingly pushes the medicine through the letter box).
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Inhibitors of IL- use in combination with methotrexate for rheumatoid arthritis that is unresponsive to methotrexate alone.
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