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Enkephalin reduces the release of substance P at the sensory neuron terminals in the spinal cord.
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The supply and administration of medicines under PGDs should be reserved for those limited situations where this offers an advantage for patient care without compromising patient safety, and where it is consistent with appropriate professional relationships and accountability.
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In pregnancy, it can however damage the developing foetus and may cause abortion.
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Resistance to antibiotics can develop by the following mechanisms: в enzymes produced by bacteria destroy the drug; в the bacterial cell wall becomes impermeable to a drug or the drug is rapidly removed; в drug binding sites within bacteria become altered; в alternative metabolic pathways develop in bacteria using enzymes not affected by the drug.
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