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PBaroreceptors beyond send impulses to the united centre. If hay pressure rises, the absence of impulses being sent to the cellular centre increases. In cheap aurogra to this, the respiratory centre reduces heart rate and force of anaesthesia by decreasing sympathetic stimulation and increasing parasympathetic stimulation of the exact. At the same true sympathetic stimulation of blood vessels decreases.
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Sequestration into adipose tissue can make anaesthetizing obese people hazardous because it is difficult to control the amount of free drug in the circulation. Similarly, benzodiazepines can be difficult to clear from the body because they are stored in large amounts in adipose tissue. This can complicate withdrawal from their use. Apart from storage in lipid tissue, certain drugs can be preferentially taken up or sequestered into other tissues.
For example, griseofulvin has an affinity for keratin. Since this drug can be used to treat fungal infections of the skin and nails its sequestration into keratin is something of an advantage.
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Overdose occurs when plasma levels of local anaesthetic are such that systemic effects appear. Overdose can be due to the patient receiving a dose larger than is appropriate (absolute overdose), or because the patient is intolerant of the local anaesthetic and has increased sensitivity to its effects.
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The site of action is in the brain, probably the medulla, and the effect is to reduce sympathetic output. Examples of centrally acting antihypertensives are methyldopa and clonidine. Methyldopa becomes converted to methylnoradrenaline, which is a false transmitter with reduced effect on noradrenaline receptors in the brain.
Clonidine stimulates presynaptic receptors on sympathetic neurons in the brain, which reduces the amount of noradrenaline released. Through both of these mechanisms, there is a decrease in sympathetic output to the peripheral blood vessels.