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Epilepsy is caused by abnormal high-frequency firing of neurons, either in the whole of the cerebral cortex or in discrete areas of the cerebral cortex (partial epilepsy).
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Fluorouracil is a pyrimidine analogue that substitutes for uracil in the synthesis pathway for thymidylate, a necessary step in the synthesis of DNA.
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For example instead of having to be referred back to a doctor and having to make another journey, a patient could be managed by the physiotherapist.
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Dithranol can cause inflammation, so initially concentrations no greater than should be applied for off.
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Bupivacaine is often used to produce continuous epidural anaesthesia during labour.
Hypersecretion of aldosterone (Connвs syndrome) is treated with an aldosterone antagonist. Hypersecretion of cortisol (Cushingвs syndrome) and testosterone are managed with surgery or irradiation.
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Terbinafine inhibits the enzyme that converts a substance called squalene to ergosterol. This results in a build up of squalene and leakage of cellular contents.
They have described the use of xvi PREFACE various forms of access, supply, administration and prescription of medicines in their professions today and considered future developments in the light of the recent legislation allowing pharmacists and nurses to train as independent prescribers. Hopefully this will give the reader a realistic view of what is currently happening and what might happen in non-medical prescribing. Useful web sites are listed at the end of each chapter, to encourage the reader to use the Internet for sources of reliable and respectable up-to-date information about disease, medicines and therapeutics.
Although all websites were accessible at the time of writing, their existence cannot be guaranteed in the future. Each chapter is followed by one or more case studies to illustrate the clinical use of drugs and problems that may arise from drugвdrug interactions and adverse reactions.
The advantages of physiotherapy supplementary prescribing in the community are that both patients and physiotherapists benefit in many ways. For example instead of having to be referred back to a doctor and having to make another journey, a patient could be managed by the physiotherapist. This could provide timely and appropriate access to treatment for chronic disease management. A community physiotherapist treating a patient in a remote location who is not responding well to medicines prescribed by a consultant could, under a CMP, alter dosages for that patientвs benefit.
Specialist knowledge allows the physiotherapist to explain to patients in these situations how to take their medication for best effect and could help improve compliance.